Testolone (RAD140)

Just when one thought that LGD-4033 and Ostarine were the most potent muscle building SARMS, Radius Health Inc. announced the development of RAD140 (Testolone), one of their most promising new compounds that was being developed as an alternative to TRT.

Anything that’s being developed as an alternative to testosterone automatically garners a lot of attention.

Before you knew, RAD140 was on supplement shelves and the recreational bodybuilding community was calling it ‘THE’ most potent SARM ever particularly due to the aggression that it causes.

But then, some users started to notice that the testosterone suppression with RAD was a lot stronger than they expected it to be.

Also, due to the hormonal fluctuation, some guys even noticed that their Estrogen levels were shooting up.

Not the best of scenarios to be caught in, we tell you.

Well, that explains that RAD140 is indeed very strong and potent. But there’s a way to use it for your bodybuilding goals.

If you are caught lollygagging, it will hit you bad with both androgenic and estrogenic sides.

Here’s a first timers guide to RAD140 and how you can use it to get some great results in your first SARMS cycle.

What is RAD140?

RAD140 is a SARM that is being developed by Radius Health Inc. as a potential therapeutic alternative for current breast cancer treatments as well as for Benign Prostatic Hyperplasia.

However, due to its strong affinity to bind to androgen receptors in muscle and bone tissue, it is also being considered as a possible TRT replacement. 

This has earned it the ‘Testolone’ nickname in bodybuilding circles.

RAD140 has all the classic properties of an effective SARM. Selective affinity to bone and muscle, excellent oral bioavailability, non-reactive to 5-alpha reductase, non-aromatizing and non-liver toxic.

However, it is still in pre-clinical trials and Phase 1 of human trials are yet to begin.

This means that all the evidence that we have about RAD-140’s effectiveness is based on animal studies and anecdotal reviews.

But what we’ve heard so far seems to be extremely positive and Testolone displays both, a very good safety profile as well as great pharmacokinetics.

The main uses of Testolone

Most SARM users get confused while choosing between RAD140 and LGD-4033 as both these compounds are touted to be very good muscle builders.

However, there’s a sea of difference in the results that you can achieve with these.

Dry Gains:

In one of the preclinical rodent-based studies, RAD140 was administered at an extremely low dose of 0.1 mg/kg and yet, it led to a 10% increase in the mean weight of the rats. Which means it is a remarkable compound for lean muscle gain. But the gains that you make on a Testolone cycle will be dry with very little water retention. Think of it like a mini Trenbolone cycle. The muscle fullness and pumps will be crazy. The veins will be more visible than ever.

Fat Loss:

When your lean body mass increases, it also increases your Total daily energy expenditure, which in turn enhances your basal metabolic rate. In other words, you burn fat. When you can build muscle and burn fat at the same time, it translates into quick body recomposition. A result that was considered impossible until now without using anabolic steroids.

Reduces Prostate size:

One of the challenges that healthy adult males face while using exogenous testosterone is the possibility of their prostate glands enlarging due to the androgenic activity of the compound. But with RAD140, the effect is quite the opposite. It stimulates the anabolic effects of testosterone while reducing the prostate in size by up to 70%. We can think of so many anabolic steroid stacks that would work a lot more effectively with RAD140.

Strength and Aggression:

There have been countless anecdotal reviews that cite that RAD140 causes a spurt in aggression. Typically, this is observed when the androgen index spikes up in the body. This indicates that either RAD140 is not as selective to androgen receptors in humans than what one expects it to be. Or, the dose that’s being used recreationally is a lot more than what’s needed. Having said that, we know a lot of users who use RAD140 specifically for the aggression. They compare it to the rush that Anadrol causes.

Side Effects of Testolone

It surprises us to read about SARMS on messaging boards these days because nobody seems to be talking about the side effects.

Either these posts have a hidden agenda (Shill) or they have never used the SARM themselves and are just rehashing stuff that they might have read on the internet.

Here are some of the side effects that RAD140 can cause.

Hair Loss:

Despite having one of the best anabolic to androgenic ratios in preclinical animal models, RAD140 displays considerable androgenic activity in humans at performance enhancement doses. This might lead to accelerated hair loss, which may be acute telogen effluvium, or temporary hair loss.

Or it might be androgenic alopecia which is caused due to strong androgens.

Irrespective of which one it is, you can be rest assured that the hormonal imbalance will trigger hair loss when you use Testolone.

Gyno:

There are very few anecdotal reviews of Testolone causing gyno since it does not aromatize. But it is a possibility that you cannot ignore. Always have a SERM handy and read up on the early symptoms of gynecomastia.

Lipids:

RAD140 will lowed your lipids. This includes HDL, LDL and triglycerides. While the latter can be beneficial, it is lowering of HDL that is concerning. The lipid lowering effect of Testolone is dose dependent by the way.

Suppression:

RAD140 is one of the most suppressive SARMS ever. The only other SARM that is more suppressive is S23. By the end of your cycle, you will be suppressed by as much as 50%. Or maybe more depending on how you react to it. So, PCT might be required to speed up recovery of your HPTA.

How to use RAD140 effectively

RAD140 is a very versatile compound that can be used in both, a bulking as well as a cutting cycle.

Doses for both are identical. You can use between 20-30mg/day for 8-weeks. Not 12-weeks mind you.

Also, if you are using SARMS for the first time, start low with 10mg/day for a couple of weeks and then ramp it up slowly.